Singula Bio news and publications

A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals.

Demetriou P, Abu-Shah E, Valvo S, McCuaig S, Mayya V, Kvalvaag A, Starkey T, Korobchevskaya K, Lee LYW, Friedrich M, Mann E, Kutuzov MA, Morotti M, Wietek N, Rada H, Yusuf S, Afrose J, Siokis A; Oxford IBD Cohort Investigators, Meyer-Hermann M, Ahmed AA, Depoil D, Dustin ML.
Nat Immunol. 2020 Oct;21(10):1232-1243. doi: 10.1038/s41590-020-0770-x. Epub 2020 Sep 14.

PMID: 32929275

Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells.

Prota G, Gileadi U, Rei M, Lechuga-Vieco AV, Chen JL, Galiani S, Bedard M, Lau VWC, Fanchi LF, Artibani M, Hu Z, Gordon S, Rehwinkel J, Enríquez JA, Ahmed AA, Schumacher TN, Cerundolo V.
Cancer Immunol Res. 2020 May;8(5):685-697. doi: 10.1158/2326-6066.CIR-19-0467. Epub 2020 Mar 23.

PMID: 32205315

A highly accurate platform for clone-specific mutation discovery enables the study of active mutational processes.

KaramiNejadRanjbar M, Sharifzadeh S, Wietek NC, Artibani M, El-Sahhar S, Sauka-Spengler T, Yau C, Tresp V, Ahmed AA.
Elife. 2020 Apr 7;9:e55207. doi: 10.7554/eLife.55207.

Free PMC article.

PMID: 32255426

The Repertoire of Serous Ovarian Cancer Non-genetic Heterogeneity Revealed by Single-Cell Sequencing of Normal Fallopian Tube Epithelial Cells.

Hu Z, Artibani M, Alsaadi A, Wietek N, Morotti M, Shi T, Zhong Z, Santana Gonzalez L, El-Sahhar S, KaramiNejadRanjbar M, Mallett G, Feng Y, Masuda K, Zheng Y, Chong K, Damato S, Dhar S, Campo L, Garruto Campanile R, Soleymani Majd H, Rai V, Maldonado-Perez D, Jones S, Cerundolo V, Sauka-Spengler T, Yau C, Ahmed AA.
Cancer Cell. 2020 Feb 10;37(2):226-242.e7. doi: 10.1016/j.ccell.2020.01.003.

PMID: 32049047